Dive into a microscopic alien world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive 70 different microbes across 4 game modes, each with multiple ascension levels ("depths").

Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!

Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
Bomb + Bomb doubles down on explosive power to make Bazooka!
Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!

25 Turrets with unique strengths and functions
48 Perks to mix and match that drastically change how you play
72 Turret & Weapon Mods that can turn shots into sticky mines or bouncing fireballs
28 Mutations that alter the challenges you face each run

20-minute Runs that can be continued in Endless Mode
50 Ambient & Electronic Tunes that adapt to the current mood and intensity
100 Steam Achievements
Accessibility Settings for colourblindness and motion sickness
Plays great on Steam Deck! (official Steam Deck Compatibility Review pending)

Genome Guardian is a product of passion - a culmination of everything I love about roguelite shooters, and a novel 'weapon-combining' feature that I've wanted to realize since I was a teenager. Your support will mean content updates and allow me to make more games in the future.

Genome Guardian screenshots