South Bronx Prep.

If you take the flask from Mrs. Ortiz room and then go downstairs to Mrs. Orsi, she will tell you a "joke of the day."

If you disregard Mrs. Peterkins on the 2nd floor, you will a character who states a topical meme.

If you find the secret room with money, the store clerks will react differently to you. Dr. Flanagan & Mrs. O will also say something different. 

Don't forget to say hello to Mr.  D'Amore on the basketball court.