Minimum:

OS: 10.8.5 (Mountain Lion), 10.9.5 (Mavericks), 10.10.5 (Yosemite), 10.11.1 (El Capitan)
Processor: Intel Core 2 Duo (Dual-Core) CPU Speed: 2.4 GHz
Memory: 2 GB RAM
Hard Disk Space: 8 GB
Video Card (ATI): Radeon HD 2600
Video Card (NVidia): Geforce 8600
Video Card (Intel): HD 4000
Video Memory (VRam): 256MB

Multiplayer: Internet (TCP/IP) and LAN (TCP/IP) play supported. Please note, it is possible for Mac and PC to become out of sync during updates. Within this short time period, Mac users will only be able to play other Mac users.
NOTICE:This game is not supported on volumes formatted as Mac OS Extended (Case Sensitive)
NOTICE: The following video chipsets are not supported for Civilization V:
ATI Radeon X1000 series, HD 2400
Nvidia GeForce 7000 series, 8600, 9400
Intel GMA (950/X3100), HD 3000

NOTICE:The Mac version is only available in English, French, Italian, German, and Spanish.

Sid Meier's Civilization V videos