The game follows both protagonists of the series: Edward Elric and his younger brother, Alphonse, as their explore lands full of giant creatures known as chimeras as well as thieves. Once meeting a girl named Armony, the two brothers start learning where the chimeras come from. The player primarily controls Edward, an alchemist who can transform objects from the game's stages into weapons to defeat his enemies. Additionally, he can receive support by Alphonse's AI in order to fight multiple enemies.

Despite good sales in Japan, critical reception to the game has been largely negative. Critics have been divided on the game's graphics and gameplay. However, the story has also received praise for the cast's characterization while other reviewers found it easy to predict the twists and outcomes.