Edmund McMillen, the creator of The Binding of Isaac and Super Meat Boy, announced that he is going to release a card game in Isaac's universe. It is now on Kickstarter with a moderate goal of $50,000 (it's not reached yet but soon will be).

https://www.kickstarter.com/projects/isaacfoursouls/the-binding-of-isaac-four-souls 

Check out these amazing designs below. And go to Kickstarter to back the guy and read more about the very idea of the game and the work process.